Pemphigus Vulgaris and Pemphigus Foliaceus
نویسندگان
چکیده
The word “pemphigus” is derived from the Greek term "pemphix” meaning bubble or blister. Pemphigus is a group of autoimmune diseases (see Table 4) characterized by intra-epithelial blistering, resulting in superficial vesicles or bullae that easily rupture, resulting in ulceration of mucosal and/or cutaneous sites. Although rare, pemphigus causes significant morbidity and potential mortality for patients. The two main subtypes are pemphigus vulgaris (PV), and pemphigus foliaceous (PF), of which PV is the most common and clinically, the most aggressive variant, being associated with significant morbidity and mortality, composing 70% of all reported cases of pemphigus: Less common forms and variants include paraneoplastic pemphigus, drug induced pemphigus, and IgA pemphigus. This book chapter focuses on the diagnosis and treatment of PV and PF.
منابع مشابه
Incidence of pemphigus vulgaris exceeds that of pemphigus foliaceus in a region where pemphigus foliaceus is endemic: analysis of a 21-year historical series.
BACKGROUND There are two main clinical subsets of pemphigus: pemphigus vulgaris and pemphigus foliaceus. Clinical and epidemiological changes related to both types of pemphigus have been observed in the last years. OBJECTIVES To analyze a 21-year historical case series of pemphigus vulgaris and pemphigus foliaceus in the northeast region of the state of Sao Paulo, where pemphigus foliaceus is...
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BACKGROUND Pemphigus foliaceus and pemphigus vulgaris are endemic in the northeastern region of São Paulo State, Brazil. They are treated mainly with systemic corticosteroids, which may provoke osteoporosis; atherosclerosis, higher blood pressure, insulin resistance, glucose intolerance, hyperlipidemia and abdominal obesity. These side effects of corticoids also constitute criteria for the diag...
متن کاملThe value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus*
BACKGROUND Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease. OBJECTIVE The aim of this study was to analyze whether trichoscopy may be useful in aiding differential diagnosis of scalp lesions in patients with pemphigus vulgaris and pemph...
متن کاملTreatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil.
BACKGROUND Mycophenolate mofetil is increasingly being used as a corticosteroid-sparing agent in immunosuppressive regimens. OBJECTIVE To elucidate the effectiveness of mycophenolate as adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. DESIGN Historical prospective study. SETTING University hospital. PATIENTS The study included 42 consecutive patients...
متن کاملTransition of pemphigus vulgaris into pemphigus foliaceus confirmed by antidesmoglein ELISA profile.
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The use of ELISA in pemphigus
Pemphigus is a group of autoimmune blistering diseases. There had been abundant evidence that antibodies against components within the desmosomes were responsible for its pathogenesis. The major antigens in pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 (130 kDa) and desmoglein 1 (160 kDa) respectively. They are glycoproteins belonging to the cadherin family and form part of the tr...
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